A Novel Multiplex Network-based Sensor Information Fusion Model and Its Application to Industrial Multiphase Flow System

This work was supported by National Natural Science Foundation of China under Grant No. 61473203, and the Natural Science Foundation of Tianjin, China under Grant No. 16JCYBJC18200.Peer reviewedPostprin

Multilayer brain network combined with deep convolutional neural network for detecting major depressive disorder

Acknowledgements This work was supported in part by the National Natural Science Foundation of China under Grants Nos. 61922062 and 61873181.Peer reviewedPostprin

MicroRNA profiling associated with non-small cell lung cancer: next generation sequencing detection, experimental validation, and prognostic value

[EN] Background: The average five-year survival for non-small cell lung cancer (NSCLC) patients is approximately 15%. Emerging evidence indicates that microRNAs (miRNAs) constitute a new class of gene regulators in humans that may play an important role in tumorigenesis. Hence, there is growing interest in studying their role as possible new biomarkers whose expression is aberrant in cancer. Therefore, in this study we identified dysregulated miRNAs by next generation sequencing (NGS) and analyzed their prognostic value. Methods: Sequencing by oligo ligation detection technology was used to identify dysregulated miRNAs in a training cohort comprising paired tumor/normal tissue samples (N = 32). We validated 22 randomly selected differentially-expressed miRNAs by quantitative real time PCR in tumor and adjacent normal tissue samples (N = 178). Kaplan-Meier survival analysis and Cox regression were used in multivariate analysis to identify independent prognostic biomarkers. Results: NGS analysis revealed that 39 miRNAs were dysregulated in NSCLC: 28 were upregulated and 11 were downregulated. Twenty-two miRNAs were validated in an independent cohort. Interestingly, the group of patients with high expression of both miRNAs (miR-21(high) and miR-188(high)) showed shorter relapse-free survival (RFS) and overall survival (OS) times. Multivariate analysis confirmed that this combined signature is an independent prognostic marker for RFS and OS (p = 0.001 and p < 0.0001, respectively). Conclusions: NGS technology can specifically identify dysregulated miRNA profiles in resectable NSCLC samples. MiR-21 or miR-188 overexpression correlated with a negative prognosis, and their combined signature may represent a new independent prognostic biomarker for RFS and OS.This work was supported by the RD12/0036/0025 and RD06/0020/1024 PI12-02838, ISCIII, grants from the Fondo Europeo de Desarrollo Regional (FEDER), by funds from the Proyecto de Investigacion Fundamental Orientada a la Transmision de Conocimiento a la Empresa (TRACE; TRA09-0132) and Beca Roche Oncohematologia.Gallach-Garcia, S.; Jantus-Lewintre, E.; Calabuig-Fariñas, S.; Montaner, D.; Alonso, S.; Sirera Pérez, R.; Blasco, A.... (2017). MicroRNA profiling associated with non-small cell lung cancer: next generation sequencing detection, experimental validation, and prognostic value. Oncotarget. 8(34):56143-56157. https://doi.org/10.18632/oncotarget.18603S561435615783

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Modélisation de joint hybride (soudé/collé) par éléments finis dans les conditions de service

Spot welding and adhesive bonding are widely used in joining of sheet metals, such as assembling of car body-in-white. Recently, spot weld and adhesive are combined to make weld bonded joint, which is employed to join Advanced High Strength Steel to improve the stiffness and crashworthiness of car body. In industry, the assessment of designing prior to prototype requires reliable constitutive models in terms of the prediction of the mechanical behaviors. The FE model of weld bonded joint is a new challenge as it should combine the models of spot welding and the models of adhesive. This thesis focuses on the modeling of weld bonded joint by DP600 steel and structural adhesive SikaPower®-498. The model of weld bonded joint consists of solid model and simplified model. The former is devoted to predict the behavior of weld bonded joint on small-scale specimen: KS2 and lap-shear. The latter can be used to predict the performance of large components with acceptable computational cost. As regards solid model, spot welded joint and adhesive bonded joint behaviors are separately identified by KS2 specimen under different loading path. The inhomogeneities in fusion zone and heat affected zone of spot weld are taken into account via the scaling of the flow stress of base metal. The scaling factors are calibrated by inverse identification. Gurson model is used to predict ductile fracture in heat affected zone and base metal while cohesive zone model is employed to simulate quasi-brittle fracture in the interface of fusion zone. The parameters of cohesive zone model are identified by the J-integral at the notch tip of spot weld crack. Cohesive zone elements with traction-separation-laws are also used to predict adhesive debonding. Model parameters are calibrated by Double Cantilevered Beam and End Notched Flexure specimens, corresponding to Mode-I and Mode-II fracture respectively. The model developed for spot weld is associated with adhesive model to predict weld bonded joint. As regards simplified model, connector elements are employed to predict the damage of spot weld. The parameters of connector element are identified by KS2 tests under different loading paths. Finally, the simplified model of spot welding, adhesive bonding, and weld-bonding are validated by T-joint which can represent the B-pillar of car body.Le soudage par point et le collage sont largement utilisés dans la jonction des tôles, telles que l'assemblage de caisses de voiture. Récemment, le soudage par point et le collage ont été combinés pour faire le joint hybride soudé-collé, qui est utilisé pour joindre les aciers à hautes résistances et améliorer la rigidité et la résistance aux chocs des corps de voiture. Dans l'industrie, l'évaluation de la conception avant prototype nécessite des modèles fiables de comportement en termes de prédiction des comportements mécaniques. Le modèle élément finis de joint soudé-collé est un nouveau défi car il doit combiner les modèles de soudage par points et les modèles de collage.Cette thèse se concentre sur la modélisation du joint soudé-collé par de l'acier DP600 et avec l’adhésif structurel SikaPower®-498. La modélisation peur utiliser un modèle solide ou un modèle simplifié (élément coque plus élément de connexion). Le modèle solide permet de prédire le comportement de spécimen à petite échelle: KS2 et cisaillement. Le modèle simplifié peut être utilisé pour prédire la performance des composants de grande dimension avec un coût de calcul acceptable.En ce qui concerne le modèle solide, le comportement du joint soudé et du joint collé sont identifiés séparément calibrés sur un spécimen KS2 sous trajets de chargement différents. Les inhomogénéités dans la zone de fusion et la zone affectée par la chaleur du soudage par point sont prises en compte par l'intermédiaire de facteurs d'échelle applique à la contrainte d'écoulement du métal de base. Les facteurs d'échelle sont determinés par identification inverse. Le modèle de Gurson est utilisé pour prédire la rupture ductile en zone affectée par le chaleur et dans le métal base tandis que le modèle de zone cohésive est utilisé pour simuler la rupture quasi-fragile dans l'interface de la zone de fusion. Les paramètres du modèle de zone cohésive sont identifiés par l'intégrale J à la pointe de fissure de la soudure. Des éléments de zone cohésive avec une loi traction-séparation sont également utilisés pour prédire le décollement adhésif. Les paramètres du modèle sont identifiés par des essais du type « Double Cantilevered Beam » et « End Notched Flexure », correspondant aux mode I et mode II respectivement. Le modèle élaboré pour le soudage par est associé avec le modèle de collage pour prédire le comportement et la rupture du joint soudé-collé.En ce qui concerne le modèle simplifié, des éléments de connexion sont utilisés pour prédire les endommagement des soudure par point. Les paramètres de l'élément de connexion sont identifiés par des tests de KS2 sous différents trajets de chargement. Enfin, les modèles simplifiés d'un soudage, d'un collage, et d'un soudé-collé sont validés sur une jonction en T qui peut représenter le pilier-B de carrosserie de la voiture

Design of secure watermarking scheme for watermarking protocol

Watermarking technique enables to hide an imperceptible watermark into a multimedia content for copyright protection. However, in most conventional watermarking schemes, the watermark is embedded solely by the seller, and both the seller and the buyer know the watermarked copy, which causes unsettled dispute at the phase of arbitration. To solve this problem, many watermarking protocols have been proposed using watermarking scheme in the encrypted domain. In this paper, we firstly discuss many security aspects in the encrypted domain, and then propose a new method of homomorphism conversion for probabilistic public key cryptosystem with homomorphic property. Based on our previous work, a new secure watermarking scheme for watermarking protocol is presented using a new embedding strategy in the encrypted domain. We employ an El Gamal variant cryptosystem with additive homomorphic property to reduce the computing overload of watermark embedding in the encrypted domain, and RA code to improve the robustness of the watermarked image against many moderate attacks after decryption. Security analysis and experiment demonstrate that the secure watermarking scheme is more suitable for implementing the existing watermarking protocols.<br /

An Optoelectronic Equivalent Narrowband Filter for High Resolution Optical Spectrum Analysis

To achieve a narrow bandwidth optical filter with a wide swept range for new generation optical spectrum analysis (OSA) of high performance optical sensors, an optoelectronic equivalent narrowband filter (OENF) was investigated and a swept optical filter with bandwidth of several MHz and sweep range of several tens of nanometers was built using electric filters and a sweep laser as local oscillator (LO). The principle of OENF is introduced and analysis of the OENF system is presented. Two electric filters are optimized to be RBW filters for high and medium spectral resolution applications. Both simulations and experiments are conducted to verify the OENF principle and the results show that the power uncertainty is less than 1.2% and the spectral resolution can reach 6 MHz. Then, a real-time wavelength calibration system consisting of a HCN gas cell and Fabry–Pérot etalon is proposed to guarantee a wavelength accuracy of ±0.4 pm in the C-band and to reduce the influence of phase noise and nonlinear velocity of the LO sweep. Finally, OSA experiments on actual spectra of various optical sensors are conducted using the OENF system. These experimental results indicate that OENF system has an excellent capacity for the analysis of fine spectrum structures